Sparing effect of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S at physiologic ligand saturations.

doi:10.1073/pnas.90.11.5039

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Article

Sparing effect of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S at physiologic ligand saturations.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1993

Poillon W N, Kim B C, Rodgers G P, Noguchi C T, Schechter A N

Abstract excerpt

Recent interest in therapies for sickle cell anemia based on elevating fetal Hb has made accurate estimates of the sparing effect of fetal Hb (Hb F) and other non-sickle Hbs on sickle Hb (Hb S) polymerization essential. We have developed a technique, using HbCO as surrogate for HbO2, that enables...

Topics

Anemia, Sickle Cell
Carboxyhemoglobin
Fetal Hemoglobin
Genotype
Hemoglobin A2
Hemoglobin, Sickle
Humans
Kinetics
Ligands

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