Peripheral human CD5+ and CD5- B cells may express somatically mutated VH5- and VH6-encoded IgM receptors.

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Article

Peripheral human CD5+ and CD5- B cells may express somatically mutated VH5- and VH6-encoded IgM receptors.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1993

Ebeling S B, Schutte M E, Logtenberg T

Abstract excerpt

Previous studies have indicated that a sizable fraction of adult human peripheral blood B cells may express IgM receptors encoded by somatically mutated V regions. From these studies it was uniquely associated with the peripheral blood B cell compartment, was uniquely associated with the peripheral blood B cell compartment, associated with particular VH gene segments and/or B cell subpopulations. We have...

Topics

Adult
Amino Acid Sequence
Antigens, CD
B-Lymphocyte Subsets
Base Sequence
CD5 Antigens
DNA Mutational Analysis
DNA, Complementary
Gene Expression
Genes, Immunoglobulin
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Variable Region

Immunoglobulin mu-Chains

In Vitro Techniques

Leukemia, Lymphocytic, Chronic, B-Cell

Molecular Sequence Data

Mutation

Receptors, Fc

Source

Open in PubMed

Identifiers

PMID: 7505018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7505018-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Peripheral human CD5+ and CD5- B cells may express somatically mutated VH5- and VH6-encoded IgM receptors.PMID 7505018Read ↗

High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire.Semantic proximity Read ↗

Comparable impact of mutational and selective influences in shaping the expressed repertoire of peripheral IgM+/CD5- and IgM+/CD5+ B cells.Semantic proximity Read ↗

Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.Semantic proximity Read ↗

Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation.Semantic proximity Read ↗

Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life.Semantic proximity Read ↗

Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.Semantic proximity Read ↗

Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes.Semantic proximity Read ↗

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The majority of human tonsillar CD5+ B cells express somatically mutated V kappa 4 genes.Semantic proximity Read ↗

Somatic mutations in the VH genes of high-affinity antibodies to self and foreign antigens produced by human CD5+ and CD5- B lymphocytes.Semantic proximity Read ↗

Evidence for a Large Compartment of IgM-Expressing Memory B Cells in HumansSemantic proximity Read ↗

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