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Article

Biased use of VH5 IgE-positive B cells in the nasal mucosa in allergic rhinitis.

The Journal of allergy and clinical immunology - 1 Aug 2005

Coker Heather A, Harries Helen E, Banfield Graham K, Carr Victoria A, Durham Stephen R, Chevretton Elfy, Hobby Paul, Sutton Brian J, Gould Hannah J

Abstract excerpt

BACKGROUND: IgE antibody-producing B cells are enriched in the nasal mucosa in patients with allergic rhinitis because of local class switching to IgE. The expressed IgE VH genes also undergo somatic hypermutation in situ to generate clonal families. The antigenic driving force behind these events is unknown. OBJECTIVE: To examine the possible involvement of a superantigen in allergic rhinitis, we compared the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16083804
DOI: 10.1016/j.jaci.2005.04.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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