Article
Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation.
Cell - 9 Apr 1993
Lassoued K, Nuñez C A, Billips L, Kubagawa H, Monteiro R C, LeBlen T W, Cooper M D
Abstract excerpt
Surrogate light chain (psi LC) genes are transcriptionally active in progenitor B (pro-B) cells before immunoglobulin genes are rearranged. Current hypothetical models suggest that the psi LC proteins may couple with surrogate or conventional heavy chain proteins to form cell surface receptors th...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Surface
- B-Lymphocytes
- Cell Differentiation
- Cell Line
- Epitopes
- Humans
- Hybridomas
- Immunoglobulin Light Chains
- Immunoglobulin Light Chains, Surrogate
- Immunoglobulin mu-Chains
- Membrane Glycoproteins
- Mice
- Models, Biological
- Phenotype
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
- Pseudogenes