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Article

Novel mechanisms control the folding and assembly of λ5/14.1 and VpreB to produce an intact surrogate light chain

16 Mar 1999

Abstract excerpt

Surrogate light chain, which escorts the mu heavy chain to the cell surface, is a critical component of the pre-B cell receptor complex. The two proteins that comprise the surrogate light chain, VpreB and lambda5/14.1, contain both unique regions and Ig-like domains. The unique regions have been postulated to function in the assembly of the surrogate light chain. However, by using transient transfection of COS7...

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Identifiers

PMID: 10077633
DOI: 10.1073/pnas.96.6.3041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Novel mechanisms control the folding and assembly of λ5/14.1 and VpreB to produce an intact surrogate light chainPMID 10077633Read ↗

A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines.Semantic proximity Read ↗

Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines.Semantic proximity Read ↗

Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation.Semantic proximity Read ↗

Gene conversion events contribute to the polymorphic variation of the surrogate light chain gene lambda 5/14.1.Semantic proximity Read ↗

The unique and immunoglobulin-like regions of surrogate light chain component lambda5 differentially interrogate immunoglobulin heavy-chain structure.Semantic proximity Read ↗

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