CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells.

doi:10.1016/s1074-7613(00)80607-x

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Article

CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells.

Immunity - 1 Aug 1998

Cerutti A, Schaffer A, Shah S, Zan H, Liou H C, Goodwin R G, Casali P

Abstract excerpt

We used our monoclonal model of germinal center maturation, CL-01 B cells, to investigate the role of CD30 in human B cell differentiation. CL-01 cells are IgM+ IgD+ CD30+ and switch to IgG, IgA, and IgE when exposed to CD40L and IL-4. Switching is hampered by CD30 coengagement, possibly through...

Topics

Antibodies, Monoclonal
B-Lymphocytes
CD40 Antigens
CD40 Ligand
Cytokines
Down-Regulation
Gene Expression Regulation
Humans
Immunoglobulin A
Immunoglobulin Class Switching
Immunoglobulin Constant Regions
Immunoglobulin D
Immunoglobulin E
Immunoglobulin G
Immunoglobulin Heavy Chains

Source

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Identifiers

PMID: 9729045
DOI: 10.1016/s1074-7613(00)80607-x
PMCID: PMC4621001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9729045-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Immunoglobulin M

Interleukin-12

Interleukin-6