Article
Mutations within the primer binding site of the human immunodeficiency virus type 1 define sequence requirements essential for reverse transcription.
Virology - 15 Jun 1996
Wakefield J K, Morrow C D
Abstract excerpt
The primer binding site (PBS) is involved in two stages during the reverse transcription of the retroviral RNA genome. In the early stage, the PBS provides complementary sequences through which tRNA(Lys,3) binds the viral RNA genome to initiate minus-strand DNA synthesis; in the later stages, com...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Line, Transformed
- Chlorocebus aethiops
- DNA, Viral
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- RNA
- RNA, Transfer, Lys
- RNA, Viral
- Transcription, Genetic