Mutations within the primer binding site of the human immunodeficiency virus type 1 define sequence requirements essential for reverse transcription.

Abstract excerpt

The primer binding site (PBS) is involved in two stages during the reverse transcription of the retroviral RNA genome. In the early stage, the PBS provides complementary sequences through which tRNA(Lys,3) binds the viral RNA genome to initiate minus-strand DNA synthesis; in the later stages, complementarity between the plus- and minus-strand copies of the PBS is required to facilitate the second template...

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