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Article

Sirtuin inhibition increases the rate of non-homologous end-joining of DNA double strand breaks.

Acta biochimica Polonica - 1 Jan 2007

Wojewódzka Maria, Kruszewski Marcin, Buraczewska Iwona, Xu Weizheng, Massuda Edmond, Zhang Jie, Szumiel Irena

Abstract excerpt

Sirtuins (type III histone deacetylases) are an important member of a group of enzymes that modify chromatin conformation. We investigated the role of sirtuin inhibitor, GPI 19015, in double strand break (DSB) repair in CHO-K1 wt and xrs-6 mutant cells. The latter is defective in DNA-dependent protein kinase (DNA-PK)-mediated non-homologous end-joining (D-NHEJ). DSB were estimated by the neutral comet assay and...

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PMID: 17311110

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GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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