Tel1/ATM prevents degradation of replication forks that reverse after topoisomerase poisoning.

doi:10.15252/embr.201745535

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Article

Tel1/ATM prevents degradation of replication forks that reverse after topoisomerase poisoning.

EMBO reports - 1 Jul 2018

Menin Luca, Ursich Sebastian, Trovesi Camilla, Zellweger Ralph, Lopes Massimo, Longhese Maria Pia, Clerici Michela

Abstract excerpt

In both yeast and mammals, the topoisomerase poison camptothecin (CPT) induces fork reversal, which has been proposed to stabilize replication forks, thus providing time for the repair of CPT-induced lesions and supporting replication restart. We show that Tel1, the Saccharomyces cerevisiae orthologue of human ATM kinase, stabilizes CPT-induced reversed forks by counteracting their nucleolytic degradation by the...

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PMID: 29739811
DOI: 10.15252/embr.201745535
PMCID: PMC6030699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.