Article
Renin inhibitors as an example of presumptive irrelevant positive findings in the Salmonella/mammalian microsome assay (Ames test).
Mutation research - 1 Feb 1993
Albertini S, Gocke E
Abstract excerpt
An increase in the number of mutant colonies in the Ames test is generally taken as a strong indication for a genotoxic (e.g., DNA damaging) property of the test compound or its metabolites. However, a few examples are known in which mechanisms usually related to some sort of growth enhancement will lead to increases in mutant frequencies of spontaneous origin. The renin inhibitor Ro 42-5892 increased the number...
Topics
- False Positive Reactions
- Histidine
- Imidazoles
- Liver Extracts
- Microsomes, Liver
- Mutagenicity Tests
- Mutation
- Renin
- Salmonella typhimurium