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Article

Mutagenic activity of 5 thiazole compounds in the Salmonella/microsome and mouse lymphoma TK+/- assays.

Mutation research - 1 Jan 2000

Cameron T P, Hughes T J, Kirby P E, Palmer K A, Fung V A, Dunkel V C

Abstract excerpt

To aid in the selection of chemical candidates for in vivo tests, the mutagenicity of 5 thiazole compounds was evaluated in the Salmonella plate incorporation assay and mouse lymphoma L5178Y TK+/- assay. Two of the compounds, 2-thiazolamine and 3-methyl-5-isothiazolamine, were positive in both assays; and one, thiazole, was negative. With the other 2 compounds the results were nonconcordant:...

Topics

Animals
Biotransformation
Cell Survival
Cells, Cultured
Lymphoma
Mice
Microsomes, Liver
Mutagenicity Tests
Mutation
Salmonella typhimurium
Thiazoles
Thymidine Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 3881663
DOI: 10.1016/0165-1218(85)90020-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3881663-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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