Article
Mutagenicity testing with TA97 and TA102 of 30 DNA-damaging compounds, negative with other Salmonella strains.
Mutation research - 1 Jan 2000
De Flora S, Camoirano A, Zanacchi P, Bennicelli C
Abstract excerpt
In a comparative study on 135 compounds of various chemical classes, 30 agents inducing direct nonreparable DNA damage in repair-deficient E. coli failed in reverting strains TA1535, TA1537, TA1538, TA98 and TA100 of S. typhimurium (De Flora et al., 1984b). These compounds were re-assayed in the Ames test using strains TA97 and TA102. A dose-dependent mutagenic response was detected with aminoantipyrine and...
Topics
- DNA Repair
- DNA, Bacterial
- Mutagenicity Tests
- Mutagens
- Mutation
- Salmonella typhimurium
- Species Specificity