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Article

Mutagenicity of 2 anti-chagasic drugs and their metabolic deactivation.

Mutation research - 1 Jan 2000

Nagel R, Nepomnaschy I

Abstract excerpt

2 anti-chagasic drugs, nifurtimox and benznidazole, were assayed in the Salmonella/mammalian microsome test. These drugs were most active in strain TA100. Under certain experimental conditions, addition of rat-liver S9 mix led to a decrease in the number of his+ revertants induced by the drugs.

Topics

Animals
Biotransformation
Chagas Disease
Humans
Microsomes, Liver
Mutagenicity Tests
Mutagens
Mutation
Nifurtimox
Nitrofurans
Nitroimidazoles
Rats
Salmonella typhimurium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Trypanocidal Agents

Source

Identifiers

PMID: 6406881
DOI: 10.1016/0165-1218(83)90124-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-6406881-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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