Article
Mutagenicity and effect on gap-junctional intercellular communication of 4,4'-methylenebis(2-chloroaniline) and its oxidized metabolites.
Mutagenesis - 1 Jan 1991
Kuslikis B I, Trosko J E, Braselton W E
Abstract excerpt
Oxidized metabolites of 4,4'-methylenebis(2-chloroaniline) (MBOCA) were tested for direct mutagenicity in a Salmonella typhimurium assay and for effects on gap-junctional communication of WB-F344 rat liver cells. The mutagenicities of the N-hydroxy, mononitroso and o-hydroxy (ring) metabolites of...
Topics
- Animals
- Cell Communication
- Cell Line
- Cell Survival
- Colony-Forming Units Assay
- Intercellular Junctions
- L-Lactate Dehydrogenase
- Liver
- Methylenebis(chloroaniline)
- Mutagenicity Tests
- Mutation
- Oxidation-Reduction
- Rats
- Rats, Inbred Strains
- Salmonella