Absence of genotoxic activity of penbutolol in bacterial and mammalian cell screening systems.

doi:10.1016/0165-1218(90)90039-5

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Article

Absence of genotoxic activity of penbutolol in bacterial and mammalian cell screening systems.

Mutation research - 1 Oct 1990

Müller W, Cojocel C, Kramer W, Mayer D

Abstract excerpt

The genotoxic potential of the beta-adrenergic blocker penbutolol was assessed using the Ames and HGPRT tests, unscheduled DNA synthesis (UDS) and alkaline elution assays. In the Ames test, penbutolol was tested for cytotoxicity and genotoxic activity in concentration ranges of 0.8-500 micrograms...

Topics

Animals
Biotransformation
Cell Line
Cell Survival
Cricetinae
DNA Damage
DNA Replication
Male
Mutagenicity Tests
Mutation
Penbutolol
Rats
Rats, Inbred Strains
Salmonella typhimurium
Time Factors

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