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Article

Bioluminescent Salmonella reverse mutation assay: a screen for detecting mutagenicity with high throughput attributes.

Mutagenesis - 1 Sept 2007

Aubrecht Jiri, Osowski Jeffery J, Persaud Prita, Cheung Jennifer R, Ackerman Joel, Lopes Sarah H, Ku Warren W

Abstract excerpt

Here, we describe the development and evaluation of a novel bioluminescent high-throughput Salmonella reverse mutation assay applicable to the screening of large numbers of small molecules. The bioluminescent Salmonella assay utilizes genetically engineered standard Salmonella tester strains TA98 and TA100 expressing the lux(CDABE) operon from Xenorhabdus luminescence. In principle, the assay employs...

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PMID: 17656636
DOI: 10.1093/mutage/gem022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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