Genetic effects of isoniazid and the relationship to in vivo and in vitro biotransformation.

doi:10.1016/0165-1218(84)90093-4

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Article

Genetic effects of isoniazid and the relationship to in vivo and in vitro biotransformation.

Mutation research - 1 Jan 2000

Braun R, Jäkel H P, Schöneich J

Abstract excerpt

The mutagenic activity of isoniazid, N-acetyl-isoniazid and hydrazine dihydrochloride was investigated in S. typhimurium. Isoniazid was found to possess a weak mutagenic activity only in repair-deficient strains TA1535 and TA100 as well as in the plasmid-containing strain TA92 (10-30 mg/plate) in...

Topics

Animals
Biotransformation
Cricetinae
Hydrazines
Isoniazid
Male
Mesocricetus
Mice
Mice, Inbred Strains
Microsomes, Liver
Mutagenicity Tests
Mutagens
Mutation
Rats
Rats, Inbred Strains
Salmonella typhimurium
Structure-Activity Relationship

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