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Article

Genetic effects of isoniazid and the relationship to in vivo and in vitro biotransformation.

Mutation research - 1 Jan 2000

Braun R, Jäkel H P, Schöneich J

Abstract excerpt

The mutagenic activity of isoniazid, N-acetyl-isoniazid and hydrazine dihydrochloride was investigated in S. typhimurium. Isoniazid was found to possess a weak mutagenic activity only in repair-deficient strains TA1535 and TA100 as well as in the plasmid-containing strain TA92 (10-30 mg/plate) in the Ames test without metabolic activation. Addition of microsomal enzymes by S9 mix decreased this direct mutagenic...

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PMID: 6381996
DOI: 10.1016/0165-1218(84)90093-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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