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Article

Modulation of cell spreading and migration by pp125FAK phosphorylation.

The American journal of pathology - 1 Sept 1995

Sankar S, Mahooti-Brooks N, Hu G, Madri J A

Abstract excerpt

We provide evidence for both matrix-dependent and pp60v-src tyrosine kinase-dependent modulation of cell migration via tyrosine phosphorylation of pp125FAK, a focal adhesion kinase, thought to be involved in integrin-mediated signaling. Enhanced pp125FAK tyrosine phosphorylation and cell spreading was associated with decreased migration. Cells plated on type I collagen were less spread and exhibited lower levels...

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Identifiers

PMID: 7677174
PMCID: PMC1870973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Modulation of cell spreading and migration by pp125FAK phosphorylation.PMID 7677174Read ↗

Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation.Semantic proximity Read ↗

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK.Semantic proximity Read ↗

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation.Semantic proximity Read ↗

v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts.Semantic proximity Read ↗

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.Semantic proximity Read ↗

FAK phosphorylation at Ser-843 inhibits Tyr-397 phosphorylation, cell spreading and migration.Semantic proximity Read ↗

Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration.Semantic proximity Read ↗

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration.Semantic proximity Read ↗

p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo.Semantic proximity Read ↗

p59fyn-p125FAK cooperation in development of CD4+CD8+ thymocytes.Semantic proximity Read ↗

Focal adhesion kinase is negatively regulated by phosphorylation at tyrosine 407.Semantic proximity Read ↗

JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration.Semantic proximity Read ↗

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