Modulation of cell spreading and migration by pp125FAK phosphorylation.

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Article

Modulation of cell spreading and migration by pp125FAK phosphorylation.

The American journal of pathology - 1 Sept 1995

Sankar S, Mahooti-Brooks N, Hu G, Madri J A

Abstract excerpt

We provide evidence for both matrix-dependent and pp60v-src tyrosine kinase-dependent modulation of cell migration via tyrosine phosphorylation of pp125FAK, a focal adhesion kinase, thought to be involved in integrin-mediated signaling. Enhanced pp125FAK tyrosine phosphorylation and cell spreading was associated with decreased migration. Cells plated on type I collagen were less spread and exhibited lower levels...

Topics

3T3 Cells
Animals
Aorta
Cattle
Cell Adhesion Molecules
Cell Line, Transformed
Cell Movement
Endothelium, Vascular
Extracellular Matrix
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Oncogene Protein pp60(v-src)

Phosphorylation

Protein-Tyrosine Kinases

Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 7677174
PMCID: PMC1870973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7677174-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Modulation of cell spreading and migration by pp125FAK phosphorylation.PMID 7677174Read ↗

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