Article
v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts.
Oncogene - 1 Jun 1995
Fincham V J, Wyke J A, Frame M C
Abstract excerpt
Morphological transformation of cells by the v-Src tyrosine kinase is incompletely understood. However, it is independent of nuclear functions and probably involves phosphorylation of targets associated with the cytoskeleton and focal adhesions, structures which tether the cytoskeleton to the points of cell attachment. v-Src activity both stimulates tyrosine phosphorylation of a tyrosine kinase present in focal...
Topics
- Animals
- Cell Adhesion Molecules
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cells, Cultured
- Chick Embryo
- Focal Adhesion Kinase 1
- Focal Adhesion Protein-Tyrosine Kinases
- Hydrolysis
- Mutation
- Oncogene Protein pp60(v-src)