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Article

p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo.

Journal of cell science - 1 Dec 2000

Wang D, Grammer J R, Cobbs C S, Stewart J E, Liu Z, Rhoden R, Hecker T P, Ding Q, Gladson C L

Abstract excerpt

p125 focal adhesion kinase (p125FAK) is a cytoplasmic tyrosine kinase that is activated upon engagement of integrin cell adhesion receptors, and initiates several signaling events that modulate cell function in vitro. To determine the biologic role of p125FAK in malignant astrocytic tumor cells, U-251MG human malignant astrocytoma cells were stably transfected with p125FAK cDNA using the TET-ON system, and stable...

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PMID: 11069767
DOI: 10.1242/jcs.113.23.4221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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