Article
Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation.
Molecular and cellular biology - 1 Dec 1997
Richardson A, Malik R K, Hildebrand J D, Parsons J T
Abstract excerpt
pp125FAK is a tyrosine kinase that appears to regulate the assembly of focal adhesions and thereby promotes cell spreading on the extracellular matrix. In some cells, the C terminus of pp125FAK is expressed as a separate protein, pp41/43FRNK. We have previously shown that overexpression of pp41/4...
Topics
- Animals
- Binding Sites
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Movement
- Cells, Cultured
- Chick Embryo
- Cytoskeletal Proteins
- Focal Adhesion Kinase 1
- Focal Adhesion Protein-Tyrosine Kinases
- Gene Expression
- Models, Biological
- Mutation