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Article

A subset of skin tumor modifier loci determines survival time of tumor-bearing mice.

Proceedings of the National Academy of Sciences of the United States of America - 21 Dec 1999

Nagase H, Mao J H, Balmain A

Abstract excerpt

Studies of mouse models of human cancer have established the existence of multiple tumor modifiers that influence parameters of cancer susceptibility such as tumor multiplicity, tumor size, or the probability of malignant progression. We have carried out an analysis of skin tumor susceptibility in interspecific Mus musculus/Mus spretus hybrid mice and have identified another seven loci showing either significant...

Topics

Animals
Carcinoma
Chimera
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Mice
Muridae
Phenotype
Quantitative Trait, Heritable
Regression Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Skin Neoplasms

Species Specificity

Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 10611333
DOI: 10.1073/pnas.96.26.15032
PMCID: PMC24768

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