Article
Epistatic interactions between skin tumor modifier loci in interspecific (spretus/musculus) backcross mice.
Cancer research - 15 Feb 2001
Nagase H, Mao J H, de Koning J P, Minami T, Balmain A
Abstract excerpt
The development of cancer is influenced both by exposure to environmental carcinogens and by the host genetic background. Epistatic interactions between genes are important in determining phenotype in plant and animal systems and are likely to be major contributors to cancer susceptibility in humans. Several tumor modifier loci have been identified from studies of mouse models of human cancer, and genetic...
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