Genetic architecture of mouse skin inflammation and tumour susceptibility.

doi:10.1038/nature07683

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Article

Genetic architecture of mouse skin inflammation and tumour susceptibility.

Nature - 26 Mar 2009

Quigley David A, To Minh D, Pérez-Losada Jesús, Pelorosso Facundo G, Mao Jian-Hua, Nagase Hiroki, Ginzinger David G, Balmain Allan

Abstract excerpt

Germline polymorphisms in model organisms and humans influence susceptibility to complex trait diseases such as inflammation and cancer. Mice of the Mus spretus species are resistant to tumour development, and crosses between M. spretus and susceptible Mus musculus strains have been used to map locations of genetic variants that contribute to skin cancer susceptibility. We have integrated germline polymorphisms...

Topics

Animals
Cell Cycle
Crosses, Genetic
Female
Gene Expression Regulation
Genetic Predisposition to Disease
Hair Follicle
Hematopoiesis
Inflammation
Male
Mice
Quantitative Trait Loci
Receptors, Calcitriol
Receptors, G-Protein-Coupled

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Identifiers

PMID: 19136944
DOI: 10.1038/nature07683
PMCID: PMC4460995

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Skin Neoplasms