Article
New chemically induced skin tumour susceptibility loci identified in a mouse backcross between FVB and dominant resistant PWK.
BMC genetics - 28 Jun 2007
Fujiwara Kyoko, Igarashi Jun, Irahara Natsumi, Kimura Makoto, Nagase Hiroki
Abstract excerpt
BACKGROUND: A variety of skin cancer susceptibility among mouse strains has allowed identification of genes responsible for skin cancer development. Fifteen Skts loci for skin tumour susceptibility have been mapped so far by using the two-stage skin carcinogenesis model [induced by 7.12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)]. A few responsible genes have been identified using...
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