Article
Use of intercross outbred mice and single nucleotide polymorphisms to map skin cancer modifier loci.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2001
Peissel B, Zaffaroni D, Pazzaglia S, Manenti G, Zanesi N, Zedda I, Rebessi S, Covelli V, Dragani T A, Saran A
Abstract excerpt
Car-R and Car-S outbred mouse lines, phenotypically selected for resistance and susceptibility to skin carcinogenesis respectively, show significant linkage disequilibrium (LD) at genetic markers mapping on chromosomal regions where skin cancer modifier loci (Skts3, Skts1, and Psl1 on Chrs 5, 7, and 9 respectively) have been mapped in standard crosses. Analysis of these regions for genetic linkage with skin...
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