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Article

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

American journal of human genetics - 1 Sept 1995

Fernandez-Salguero P, Hoffman S M, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang J D, Evans W E, Idle J R

Abstract excerpt

A group of human cytochrome P450 genes encompassing the CYP2A, CYP2B, and CYP2F subfamilies were cloned and assembled into a 350-kb contig localized on the long arm of chromosome 19. Three complete CYP2A genes--CYP2A6, CYP2A7, and CYP2A13--plus two pseudogenes truncated after exon 5, were identified and sequenced. A variant CYP2A6 allele that differed from the corresponding CYP2A6 and CYP2A7 cDNAs previously...

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Identifiers

PMID: 7668294
PMCID: PMC1801261

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