On hypervariability at the reactive center of proteolytic enzymes and their inhibitors.

doi:10.1007/BF00160406

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Article

On hypervariability at the reactive center of proteolytic enzymes and their inhibitors.

Journal of molecular evolution - 1 Dec 1994

Ohta T

Abstract excerpt

The pattern of synonymous and nonsynonymous substitutions at the reactive center of proteases (kallikrein) and their inhibitors (alpha 1-antitrypsin and serpin) was examined. In the case of alpha 1-antitrypsin, the proportion of different nonsynonymous sites exceeds that of different synonymous s...

Topics

Animals
Binding Sites
Biological Evolution
Cattle
Gene Conversion
Genetic Variation
Guinea Pigs
Humans
Kallikreins
Mice
Multigene Family
Papio
Peptide Hydrolases
Point Mutation
Protease Inhibitors
Rabbits
Rats
Selection, Genetic

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