A directional process of gene conversion is expected to yield dynamic polymorphism associated with stability of alternative alleles in class I histocompatibility antigens gene family.

Abstract excerpt

This work is a contribution to the discussion of the polymorphism of class I histocompatibility antigens (H-2 antigens in the mouse). Specially, the involvement of gene conversion in H-2 polymorphism has been explored through the use of a simplified computer model. It thus appears that in a population of limited size, gene conversion can promote allelic polymorphism while homogenizing the DNA sequences in a...

Topics

• Alleles
• Animals
• Base Sequence
• Computers
• DNA
• Gene Conversion
• H-2 Antigens
• Mice
• Models, Genetic
• Polymorphism, Genetic