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Article

The gene conversion hypothesis of MHC evolution: a review.

Immunogenetics - 1 Nov 1999

Martinsohn J T, Sousa A B, Guethlein L A, Howard J C

Abstract excerpt

Gene conversion is often invoked to explain the evolution of sequence patterns observed in major histocompatibility complex (MHC) genes and their alleles. This is the gene conversion hypothesis of MHC sequence evolution. These observations and their interpretation probably belong in a larger theoretical framework, namely the evolution of systems of resistance to rapidly evolving pathogens. This review looks...

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Identifiers

PMID: 10602879
DOI: 10.1007/s002510050593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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