Positive Darwinian selection promotes charge profile diversity in the antigen-binding cleft of class I major-histocompatibility-complex molecules.

doi:10.1093/oxfordjournals.molbev.a040626

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Article

Positive Darwinian selection promotes charge profile diversity in the antigen-binding cleft of class I major-histocompatibility-complex molecules.

Molecular biology and evolution - 1 Nov 1990

Hughes A L, Ota T, Nei M

Abstract excerpt

Certain major-histocompatibility-complex (MHC) loci are highly polymorphic, and the mechanism of maintenance of this polymorphism remains controversial. Recent studies of the pattern of nucleotide substitution at MHC loci have produced strong evidence that this polymorphism is maintained mainly b...

Topics

Alleles
Amino Acids
Animals
Base Composition
Genes, MHC Class I
Genetic Variation
Histocompatibility Antigens Class I
Humans
Mice
Polymorphism, Genetic
Selection, Genetic

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