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Article

Evolution of Mhc Class II Polymorphism: The Rise and Fall of Class II Gene Function in Primates

1 Feb 1995

Abstract excerpt

The substitution rate at the codons implicated at ARS of Mhc class II genes has previously been shown to be heavily biased towards nonsynonymous substitutions, indicative of positive selection for polymorphism. Based on our analysis of the number of synonymous changes at codons outside putative ARS in primates, the average age of the polymorphism at class II loci was found to increase in the following order:...

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PMID: 7558074
DOI: 10.1111/j.1600-065x.1995.tb00668.x

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