Article
Oncogenic Ki-ras confers a more aggressive colon cancer phenotype through modification of transforming growth factor-beta receptor III.
The Journal of biological chemistry - 12 Jan 2001
Yan Z, Deng X, Friedman E
Abstract excerpt
Transforming growth factor-beta1 (TGF-beta1) can act as a tumor suppressor or a tumor promoter depending on the characteristics of the malignant cell. Each of three Ki-ras(G12V) transfectants of HD6-4 colon cancer cells had been shown to be more aggressive in vivo than controls in earlier studies (Yan, Z., Chen, M., Perucho, M., and Friedman, E. (1997) J. Biol. Chem. 272, 30928-30936). We now show that stable...
Topics
- Activin Receptors, Type I
- Animals
- Cell Division
- Colonic Neoplasms
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Enzyme Inhibitors
- Genes, ras
- Humans
- Neoplasm Invasiveness
- Phenotype
- Protein Processing, Post-Translational
- Protein Serine-Threonine Kinases