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Article

Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections.

European journal of immunology - 1 Apr 2003

Senn Beatrice M, López-Macías Constantino, Kalinke Ulrich, Lamarre Alain, Isibasi Armando, Zinkernagel Rolf M, Hengartner Hans

Abstract excerpt

To analyze how combinatorial light (L) chain diversity influences the B cell repertoire, we studied mice with a homozygous immunoglobulin-heavy-chain null mutation (mu MT), in which the B cell developmental block was overridden by the expression of a transgenic immunoglobulin mu heavy (H) chain derived from a vesicular stomatitis virus Indiana serotype (VSV-IND)-neutralizing Ab (T11 mu MT mice). The randomly...

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Source

Identifiers

PMID: 12672061
DOI: 10.1002/eji.200323340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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