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Article

Heavy chain-only antibodies are spontaneously produced in light chain-deficient mice.

The Journal of experimental medicine - 24 Dec 2007

Zou Xiangang, Osborn Michael J, Bolland Daniel J, Smith Jennifer A, Corcos Daniel, Hamon Maureen, Oxley David, Hutchings Amanda, Morgan Geoff, Santos Fatima, Kilshaw Peter J, Taussig Michael J, Corcoran Anne E, Brüggemann Marianne

Abstract excerpt

In healthy mammals, maturation of B cells expressing heavy (H) chain immunoglobulin (Ig) without light (L) chain is prevented by chaperone association of the H chain in the endoplasmic reticulum. Camelids are an exception, expressing homodimeric IgGs, an antibody type that to date has not been found in mice or humans. In camelids, immunization with viral epitopes generates high affinity H chain-only antibodies,...

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Share to Antibodies
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Immune System

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Light Chains

Share to In Situ Hybridization, Fluorescence

Share to Recombination, Genetic

Source

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Identifiers

PMID: 18086860
DOI: 10.1084/jem.20071155
PMCID: PMC2150980

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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