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Article

Both cdc2 and cdk2 promote S phase initiation in Xenopus egg extracts.

Journal of cell science - 1 May 1995

Chevalier S, Tassan J P, Cox R, Philippe M, Ford C

Abstract excerpt

Xenopus egg extracts induce S phase DNA replication in added sperm pronuclei in a highly regulated manner, similar to events in vivo. Removal of cyclin-dependant kinases (cdks) or cdk2 from these extracts using affinity matrices severely inhibits initiation of S phase. We have used p13suc1 beads...

Topics

Animals
CDC2 Protein Kinase
CDC2-CDC28 Kinases
Cell Extracts
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinases
DNA Replication
Humans
Microinjections
Mutation
Oocytes
Oogenesis
Protein Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Serine-Threonine Kinases

RNA, Messenger

S Phase

Xenopus Proteins

Xenopus laevis

Source

Identifiers

PMID: 7657707
DOI: 10.1242/jcs.108.5.1831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7657707-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Both cdc2 and cdk2 promote S phase initiation in Xenopus egg extracts.PMID 7657707Read ↗

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Cyclin-dependent kinase inhibits reinitiation of a normal S-phase program during G2 in fission yeast.Semantic proximity Read ↗

Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle.Semantic proximity Read ↗

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Cyclin B-cdk1 kinase stimulates ORC- and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts.Semantic proximity Read ↗

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