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Article

Both cdc2 and cdk2 promote S phase initiation in Xenopus egg extracts.

Journal of cell science - 1 May 1995

Chevalier S, Tassan J P, Cox R, Philippe M, Ford C

Abstract excerpt

Xenopus egg extracts induce S phase DNA replication in added sperm pronuclei in a highly regulated manner, similar to events in vivo. Removal of cyclin-dependant kinases (cdks) or cdk2 from these extracts using affinity matrices severely inhibits initiation of S phase. We have used p13suc1 beads to remove both cdk2 and cdc2 proteins from egg extracts and developed a method to replace either protein alone to...

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Source

Identifiers

PMID: 7657707
DOI: 10.1242/jcs.108.5.1831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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