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Article

Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes.

The EMBO journal - 15 Nov 1995

Nebreda A R, Gannon J V, Hunt T

Abstract excerpt

The meiotic maturation of Xenopus oocytes triggered by progesterone requires new protein synthesis to activate both maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAP kinase). Injection of mRNA encoding mutant p34cdc2 (K33R) that can bind cyclins but lacks protein kinase activity strongly inhibited progesterone-induced activation of both MPF and MAP kinase in Xenopus oocytes. Similar...

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Identifiers

PMID: 8521817
DOI: 10.1002/j.1460-2075.1995.tb00247.x
PMCID: PMC394675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes.PMID 8521817Read ↗

Xenopus oocytes and the biochemistry of cell division.Semantic proximity Read ↗

Synthesis and accumulation of p34<sup>cdc2</sup> and cyclin B in mouse oocytes during acquisition of competence to resume meiosisSemantic proximity Read ↗

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A p90(rsk) mutant constitutively interacting with MAP kinase uncouples MAP kinase from p34(cdc2)/cyclin B activation in Xenopus oocytes.Semantic proximity Read ↗

Phosphorylation of Maskin by Aurora-A Participates in the Control of Sequential Protein Synthesis during Xenopus laevis Oocyte MaturationSemantic proximity Read ↗

Resumption of Meiosis is Initiated by the Accumulation of Cyclin B in Bovine Oocytes1Semantic proximity Read ↗

Phosphorylation of the p34(cdc2) target site on goldfish germinal vesicle lamin B3 before oocyte maturation.Semantic proximity Read ↗

Inhibition of progesterone-induced Xenopus oocyte maturation by Nm23.Semantic proximity Read ↗

The critical role of the MAP kinase pathway in meiosis II in Xenopus oocytes is mediated by p90(Rsk).Semantic proximity Read ↗

Both cdc2 and cdk2 promote S phase initiation in Xenopus egg extracts.Semantic proximity Read ↗

The temporal control of Wee1 mRNA translation during Xenopus oocyte maturation is regulated by cytoplasmic polyadenylation elements within the 3'-untranslated region.Semantic proximity Read ↗

Recombinant C1b domain of PKCdelta triggers meiotic maturation upon microinjection in Xenopus laevis oocytes.Semantic proximity Read ↗

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