Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import.

doi:10.1083/jcb.130.5.1017

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Article

Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import.

The Journal of cell biology - 1 Sept 1995

Corbett A H, Koepp D M, Schlenstedt G, Lee M S, Hopper A K, Silver P A

Abstract excerpt

The Saccharomyces cerevisiae gene, RNA1, encodes a protein with extensive homology to the mammalian Ran/TC4 GTPase activating protein. Using indirect immunofluorescence microscopy, we have demonstrated that rna1-1 mutant cells are defective in nuclear import of several proteins. The same result is obtained when nuclear import is examined in living cells using a nuclear protein fused to the naturally green...

Topics

Biological Transport
Cell Nucleus
Cytosol
Fluorescent Dyes
Fungal Proteins
GTP-Binding Proteins
GTPase-Activating Proteins
Genes, Fungal
Mutation
Nuclear Envelope
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proteins

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Substrate Specificity

Temperature

ran GTP-Binding Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 7657689
DOI: 10.1083/jcb.130.5.1017
PMCID: PMC2120547

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7657689-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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