Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Ty1 integrase protein can exploit the classical nuclear protein import machinery for entry into the nucleus.

Nucleic acids research - 1 Aug 2008

McLane Laura M, Pulliam Kanika F, Devine Scott E, Corbett Anita H

Abstract excerpt

Like its retroviral relatives, the long terminal repeat retrotransposon Ty1 in the yeast Saccharomyces cerevisiae must traverse a permanently intact nuclear membrane for successful transposition and replication. For retrotransposition to occur, at least a subset of Ty1 proteins, including the Ty1 integrase, must enter the nucleus. Nuclear localization of integrase is dependent upon a C-terminal nuclear targeting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to alpha Karyopherins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Green Fluorescent Proteins

Share to Integrases

Share to Nuclear Localization Signals

Share to ran GTP-Binding Protein

Share to Retroelements

Source

Open in PubMed Open full text

Identifiers

PMID: 18586821
DOI: 10.1093/nar/gkn383
PMCID: PMC2490736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Ty1 integrase protein can exploit the classical nuclear protein import machinery for entry into the nucleus.PMID 18586821Read ↗

The classical nuclear localization signal receptor, importin-alpha, is required for efficient transition through the G1/S stage of the cell cycle in Saccharomyces cerevisiae.Semantic proximity Read ↗

Dynamic localization of the nuclear import receptor and its interactions with transport factors.Semantic proximity Read ↗

Recombinant Adeno-Associated Virus Utilizes Host Cell Nuclear Import Machinery To Enter the NucleusSemantic proximity Read ↗

Importin-beta family members mediate alpharetrovirus gag nuclear entry via interactions with matrix and nucleocapsid.Semantic proximity Read ↗

Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import.Semantic proximity Read ↗

Nuclear import of chromatin remodeler Isw1 is mediated by atypical bipartite cNLS and classical import pathway.Semantic proximity Read ↗

Importin 7 and Nup358 Promote Nuclear Import of the Protein Component of Human TelomeraseSemantic proximity Read ↗

5′ to 3′ mRNA Decay Factors Colocalize with Ty1 Gag and Human APOBEC3G and Promote Ty1 RetrotranspositionSemantic proximity Read ↗

P-body components are required for Ty1 retrotransposition during assembly of retrotransposition-competent virus-like particles.Semantic proximity Read ↗

Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signalingSemantic proximity Read ↗

A novel conserved nuclear localization signal is recognized by a group of yeast importins.Semantic proximity Read ↗

Interaction of the Vp3 nuclear localization signal with the importin alpha 2/beta heterodimer directs nuclear entry of infecting simian virus 40.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.