Lung colonization by and heparanase activity in in vitro transformed 3T3 cells rendered highly tumorigenic by an in vivo passage.

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Article

Lung colonization by and heparanase activity in in vitro transformed 3T3 cells rendered highly tumorigenic by an in vivo passage.

Invasion & metastasis - 1 Jan 2000

Katz B Z, Ishai-Michaeli R, Zusman T, Vlodavsky I, Witz I P

Abstract excerpt

Cloned BALB/c 3T3 cells transformed in vitro with polyoma virus and maintained in culture (C cells) were compared with respect to their ability to form experimental metastases, with cells from the same clones that were passaged subcutaneously in vivo (CTC cells), thereby gaining a high tumorigeni...

Topics

3T3 Cells
Animals
Cattle
Cell Line, Transformed
Cell Transformation, Viral
Extracellular Matrix
Fibroblast Growth Factor 2
Glucuronidase
Glycoside Hydrolases
Lung Neoplasms
Mice
Mice, Inbred BALB C
Phenotype
Polyomavirus

Source

Open in PubMed

Identifiers

PMID: 7657521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7657521-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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