Interactions of exogenous heparan sulfate with tumor cells of different metastatic phenotype.

Article

Interactions of exogenous heparan sulfate with tumor cells of different metastatic phenotype.

Invasion & metastasis - 1 Jan 1990

Timar J, Moczar M, Lapis K, Moczar E

Abstract excerpt

Heparan sulfate (HS) enhanced the growth of the highly metastatic (HM) 3LL cell line, but not that of the low metastatic (LM) counterpart, in a dose-dependent way. Heparin, chondroitin sulfate, hyaluronate did not produce this effect. At 4 degrees C both cell lines exhibited high affinity binding...

Topics

Animals
Cattle
Cell Division
Extracellular Space
Glycosaminoglycans
Heparitin Sulfate
Lung Neoplasms
Mice
Neoplasm Metastasis
Phenotype
Protein Binding
Tumor Cells, Cultured

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