Relationships between heparanase activity and increasing metastatic potential of fibroblasts transfected with various oncogenes.

doi:10.1016/0304-3835(90)90101-3

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Article

Relationships between heparanase activity and increasing metastatic potential of fibroblasts transfected with various oncogenes.

Cancer letters - 15 Jun 1990

Schwarz L C, Inoue T, Irimura T, Damen J E, Greenberg A H, Wright J A

Abstract excerpt

We have examined the effects of transformation by activated H-ras and other transforming oncogenes on the activity of the enzyme, heparanase. Degradation of 3H-N-acetylated-partially N-desulfated heparan sulfate by cellular extracts of the transformants was assessed by gel permation chromatograph...

Topics

Animals
Cell Line
Cell Transformation, Neoplastic
Embryo, Mammalian
Glucuronidase
Glycoside Hydrolases
Mice
Mice, Inbred Strains
Mice, Nude
Neoplasm Metastasis
Oncogenes
Phenotype
Rats
Transfection

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