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Article

Antisense-mediated suppression of Heparanase gene inhibits melanoma cell invasion.

Neoplasia (New York, N.Y.) - 1 Mar 2005

Roy Madhuchhanda, Reiland Jane, Murry Brian P, Chouljenko Vladimir, Kousoulas Konstantin G, Marchetti Dario

Abstract excerpt

Cancer metastasis, is a frequent manifestation of malignant melanoma progression. Successful invasion into distant organs by tumor cells must include attachment to microvessel endothelial cells, and degradation of basement membranes and extracellular matrix (ECM). Heparan sulfate proteoglycans (HSPG) are essential and ubiquitous macromolecules associated with the cell surface and ECM of a wide range of cells and...

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Source

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Identifiers

PMID: 15799825
DOI: 10.1593/neo.04493
PMCID: PMC1501137

Genes

HPSE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antisense-mediated suppression of Heparanase gene inhibits melanoma cell invasion.PMID 15799825Read ↗

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