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Article

Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development.

Developmental biology - 15 Oct 2002

Tümpel Stefan, Sanz-Ezquerro Juan J, Isaac Alison, Eblaghie Maxwell C, Dobson Julia, Tickle Cheryll

Abstract excerpt

Tbx3, a T-box gene family member related to the Drosophila gene optomotor blind (omb) and encoding a transcription factor, is expressed in anterior and posterior stripes in developing chick limb buds. Tbx3 haploinsufficiency has been linked with the human condition ulnar-mammary syndrome, in which predominantly posterior defects occur in the upper limb. Omb is expressed in Drosophila wing development in response...

Topics

Animals
Body Patterning
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins
Carrier Proteins
Chick Embryo
Extremities
Gene Expression Regulation, Developmental
Hedgehog Proteins
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Mice, Mutant Strains

Mutation

Proteins

Quail

Signal Transduction

T-Box Domain Proteins

Source

Identifiers

PMID: 12376101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development.PMID 12376101Read ↗

Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling.Semantic proximity Read ↗

Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: their relationships in the signalling cascade involved in limb patterning.Semantic proximity Read ↗

Anteroposterior patterning in the limb and digit specification: contribution of mouse genetics.Semantic proximity Read ↗

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Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.Semantic proximity Read ↗

Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression.Semantic proximity Read ↗

Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.Semantic proximity Read ↗

FGF8, Wnt8 and Myf5 are target genes of Tbx6 during anteroposterior specification in Xenopus embryo.Semantic proximity Read ↗

Role of the chicken homeobox-containing genes GHox-4.6 and GHox-8 in the specification of positional identities during the development of normal and polydactylous chick limb buds.Semantic proximity Read ↗

The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limb.Semantic proximity Read ↗

The mis-expression of posterior Hox-4 genes in talpid (ta3) mutant wings correlates with the absence of anteroposterior polarity.Semantic proximity Read ↗

Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis.Semantic proximity Read ↗

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