Article
Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T-cell leukemia/lymphoma.
Blood - 1 Sept 1995
Morosétti R, Kawamata N, Gombart A F, Miller C W, Hatta Y, Hirama T, Said J W, Tomonaga M, Koeffler H P
Abstract excerpt
The protein p27KIP1 belongs to a recently identified family of proteins termed cyclin-dependent kinase inhibitors (CDKIs). These proteins play an important role in regulating cell-cycle progression and loss of their function has been implicated in tumorigenesis. Transforming growth factor beta (TGF-beta) may induce cell growth arrest through p27 activation. TGF-beta often loses its ability to arrest growth of...
Topics
- Base Sequence
- Blotting, Southern
- Burkitt Lymphoma
- Cell Cycle Proteins
- Cell Line
- Cell Line, Transformed
- Codon
- Cyclin-Dependent Kinase Inhibitor p27
- DNA Primers
- DNA, Neoplasm
- Enzyme Inhibitors