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Article

Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia.

Blood - 15 Feb 2008

Le Toriellec Emilie, Despouy Gilles, Pierron Gaëlle, Gaye Nogaye, Joiner Marjorie, Bellanger Dorine, Vincent-Salomon Anne, Stern Marc-Henri

Abstract excerpt

T-cell prolymphocytic leukemia (T-PLL) is consistently associated with inactivation of the ATM gene and chromosomal re-arrangements leading to an overexpression of MTCP1/TCL1 oncoproteins. These alterations are present at the earliest stage of malignant transformation, suggesting that additional events are required for overt malignancy. In this study, we pursued the investigation of the 12p13 deletion, previously...

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Source

Identifiers

PMID: 18073348
DOI: 10.1182/blood-2007-06-095570

Genes

MTCP1
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia.PMID 18073348Read ↗

Genetic characterization of T-PLL reveals two major biologic subgroups and JAK3 mutations as prognostic marker.Semantic proximity Read ↗

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.Semantic proximity Read ↗

Current understandings on T-cell prolymphocytic leukemia and its association with TCL1 proto-oncogeneSemantic proximity Read ↗

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Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy.Semantic proximity Read ↗

Haploinsufficiency of Bcl11b for suppression of lymphomagenesis and thymocyte development.Semantic proximity Read ↗

Transgenic Mice for MTCP1 Develop T-Cell Prolymphocytic LeukemiaSemantic proximity Read ↗

Mature T-cell Leukemia Primarily Involving Blood and Bone Marrow without TCL1 or MTCP1 Rearrangement: A Subtype of T-Prolymphocytic Leukemia or a Distinct Entity?Semantic proximity Read ↗

SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia.Semantic proximity Read ↗

Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia.Semantic proximity Read ↗

Reconstruction of rearranged T-cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T-cell prolymphocytic leukemia.Semantic proximity Read ↗

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