Article
Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia.
Blood - 15 Feb 2008
Le Toriellec Emilie, Despouy Gilles, Pierron Gaëlle, Gaye Nogaye, Joiner Marjorie, Bellanger Dorine, Vincent-Salomon Anne, Stern Marc-Henri
Abstract excerpt
T-cell prolymphocytic leukemia (T-PLL) is consistently associated with inactivation of the ATM gene and chromosomal re-arrangements leading to an overexpression of MTCP1/TCL1 oncoproteins. These alterations are present at the earliest stage of malignant transformation, suggesting that additional events are required for overt malignancy. In this study, we pursued the investigation of the 12p13 deletion, previously...
Topics
- Animals
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins
- Chromosome Mapping
- Chromosomes, Human, Pair 12
- Cyclin-Dependent Kinase Inhibitor p27
- DNA Primers
- DNA-Binding Proteins
- Gene Deletion
- Humans
- Intracellular Signaling Peptides and Proteins
- Leukemia, Prolymphocytic, T-Cell