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Article

Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions.

Immunity - 1 Apr 2002

Lee Susan S, Tranchina Daniel, Ohta Yuko, Flajnik Martin F, Hsu Ellen

Abstract excerpt

Among 631 substitutions present in 90 nurse shark immunoglobulin light chain somatic mutants, 338 constitute 2-4 bp stretches of adjacent changes. An absence of mutations in perinatal sequences and the bias for one mutating V gene in adults suggest that the diversification is antigen dependent. The substitutions shared no patterns, and the absence of donor sequences, including from family members, supports the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11970880
DOI: 10.1016/s1074-7613(02)00300-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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