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Article

C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues.

Developmental biology - 1 Oct 2010

Bosu Dimple R, Feng Hui, Min Kyoengwoo, Kim Youngjo, Wallenfang Matthew R, Kipreos Edward T

Abstract excerpt

Cullin-RING ubiquitin ligases (CRLs) are critical regulators of multiple developmental and cellular processes in eukaryotes. CAND1 is a biochemical inhibitor of CRLs, yet has been shown to promote CRL activity in plant and mammalian cells. Here we analyze CAND1 function in the context of a developing metazoan organism. Caenorhabditis elegans CAND-1 is capable of binding to all of the cullins, and we show that it...

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Identifiers

PMID: 20659444
DOI: 10.1016/j.ydbio.2010.07.020
PMCID: PMC2955628

Genes

CAND1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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