Loss of heterozygosity of imprinted genes in SV40 t/T antigen-induced hepatocellular carcinomas.

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Article

Loss of heterozygosity of imprinted genes in SV40 t/T antigen-induced hepatocellular carcinomas.

Oncogene - 17 Aug 1995

Casola S, Ungaro P, Pedone P V, Lazzaro D, Fattori E, Ciliberto G, Zarrilli R, Bruni C B, Riccio A

Abstract excerpt

Expression of the chromosomally linked Insulin-like Growth Factor II (IGF-II) and H19 genes is regulated by parental imprinting during development, since the maternally inherited IGF-II and the paternally inherited H19 alleles are inactive in fetal tissues. Here we show that expression of IGF-II and H19 genes is activated in transgenic mice during SV40 Tag-induced hepatocarcinogenesis and that imprinting of both...

Topics

Alleles
Animals
Antigens, Polyomavirus Transforming
Base Sequence
Chromosome Deletion
Chromosome Mapping
DNA Primers
DNA-Binding Proteins
Female
Fetus
Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression

Gene Expression Regulation, Neoplastic

Genetic Markers

Insulin-Like Growth Factor II

Lim Kinases

Liver Neoplasms, Experimental

Male

Source

Open in PubMed

Identifiers

PMID: 7651735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7651735-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Loss of heterozygosity of imprinted genes in SV40 t/T antigen-induced hepatocellular carcinomas.PMID 7651735Read ↗

Genomic imprinting and Igf2 influence liver tumorigenesis and loss of heterozygosity in SV40 T antigen transgenic mice.Semantic proximity Read ↗

Genetic analysis of liver tumorigenesis in SV40 T antigen transgenic mice implies a role for imprinted genes.Semantic proximity Read ↗

Hepatocellular carcinomas of the albumin SV40 T-antigen transgenic rat display fetal-like re-expression of lgf2 and deregulation of H19.Semantic proximity Read ↗

Allelic-expression imbalance of the insulin-like growth factor 2 gene in hepatocellular carcinoma and underlying disease.Semantic proximity Read ↗

Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastomaSemantic proximity Read ↗

Preferential loss of heterozygosity of chromosome 7 loci in simian virus 40 t/T antigen-induced mouse hepatocellular carcinomas does not involve H-ras mutations.Semantic proximity Read ↗

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Expression, promoter usage and parental imprinting status of insulin-like growth factor II (IGF2) in human hepatoblastoma: uncoupling of IGF2 and H19 imprinting.Semantic proximity Read ↗

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[The aberrant imprinting of insulin-like growth factor II and H19 in human hepatocellular carcinoma].Semantic proximity Read ↗

Equivalent parental distribution of frequently lost alleles and biallelic expression of the H19 gene in human testicular germ cell tumors.Semantic proximity Read ↗

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