Genomic imprinting and Igf2 influence liver tumorigenesis and loss of heterozygosity in SV40 T antigen transgenic mice.

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Article

Genomic imprinting and Igf2 influence liver tumorigenesis and loss of heterozygosity in SV40 T antigen transgenic mice.

Cancer research - 15 Oct 1997

Haddad R, Held W A

Abstract excerpt

Maternal-specific loss of heterozygosity (LOH) and allelic imbalances [i.e., partial LOH (pLOH)] observed in SV40 T/t antigen-induced liver tumors suggests that an imprinted gene on chromosome 7 is involved in liver tumorigenesis. Maternal-specific LOH/pLOH may reflect the loss of a maternally ex...

Topics

Alleles
Animals
Antigens, Viral, Tumor
Chromosome Mapping
Crosses, Genetic
Female
Genetic Markers
Genomic Imprinting
Genotype
Insulin-Like Growth Factor II
Liver
Liver Neoplasms
Loss of Heterozygosity
Male
Mice
Mice, Transgenic
Phenotype
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 9377577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9377577-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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